Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis

Completed

Conditions studied: Cirrhosis, Spontaneous Bacterial Peritonitis

In brief

The utilization of doxycycline for SBP prophylaxis is a novel practice at MDMC. Therefore, an assessment of safety and efficacy is needed in order to generalize this practice. The publication of this study can potentially introduce a new alternative to guideline-directed therapies for secondary prevention of SBP. Doxycycline is non-inferior to guideline-directed therapies regarding safety and efficacy in primary and secondary prophylaxis for SBP.

Key facts

Study ID

NCT04153604

Run by

Methodist Health System

People needed

841

Starts

2019-11-04

Expected to finish

2020-08-07

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 18 year-old with refractory ascites who are candidates for SBP prophylaxis per clinician's decision
• Patients diagnosed with cirrhosis based on clinical criteria
• Patients with a diagnosis of SBP confirmed by paracentesis

You may not qualify if…

• Patients who have secondary peritonitis other than SBP
• Patients who have a history of liver transplant prior to the initial episode of SBP
• Patients with incomplete medical records

Where it is running

• Methodist Dallas Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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