Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock
Completed
Conditions studied: Septic Shock, Weight, Body
In brief
At present, there is conflicting evidence regarding outcomes in patients with septic shock receiving weight-based vasopressor (WBVP) versus non-weight-based vasopressor (NWBVP) dosing strategies. At MCMC, a weight-based strategy is in place whereas MDMC, MMMC and MRMC currently utilize a non-weight-based dosing strategy. Obese patients (BMI \> 30) receiving either strategy may potentially be receiving substantially more or less vasopressor exposure compared to their non-obese (BMI \< 30) counterparts. Determining total vasopressor exposure and assessing clinical outcomes would benefit our institution and others by providing optimal vasopressor dosing strategies in obese and non-obese patients. There is a difference in clinical outcomes between patients receiving weight-based and non-weight-based vasopressor dosing strategies. There is a difference in total vasopressor exposure between obese and non-obese patients utilizing WBVP and NWBVP strategies.
Key facts
- Study ID
- NCT04153578
- Run by
- Methodist Health System
- People needed
- 945
- Starts
- 2019-11-04
- Expected to finish
- 2020-06-22
- Last updated by the study team
- 2026-03-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ICU admission
- Medical admission type
- Received NE, epinephrine (EPI), phenylephrine (PE), or dopamine (DA) for septic shock
- Received NE/EPI/PE/DA for > 24 hours
- Age ≥ 18 years
You may not qualify if…
- Non-sepsis indication for vasopressors
- Surgical or trauma admission type
- ICU length of stay < 24 hours
- Pregnant
Where it is running
- Methodist Dallas Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.