Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy

Completed · Phase 4

Conditions studied: Infection During Renal Replacement Therapy, Critically Ill

In brief

Dosing of ceftaroline in patients with chronic kidney disease is defined, but there is no data on pharmacokinetics and pharmacodynamics of the drug in patients receiving continuous renal replacement therapy (CRRT). The purpose of this study is to determine pharmacokinetics and pharmacodynamics of ceftaroline in a critically ill patient population receiving CRRT, in order to define a dosing recommendation in this population.

Key facts

Study ID

NCT04152694

Run by

University of Maryland, Baltimore

People needed

4

Starts

2018-03-09

Expected to finish

2020-09-01

Last updated by the study team

2021-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to an intensive care unit
• Receiving CRRT (CVVH, CVVHDF, CVVHD)
• Receiving ceftaroline

You may not qualify if…

• Pregnant patients
• Burn patients
• Patients with toxic epidermal necrolysis or Stevens-Johnson syndrome
• Patients prescribed extended infusion ceftaroline

Where it is running

• University of Maryland Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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