Lenalidomide Monotherapy in R/R DLBCL

Completed

Conditions studied: Diffuse Large B Cell Lymphoma

In brief

This observational study is designed to characterise the effectiveness of lenalidomide monotherapy in the treatment of R/R DLBCL and to compare the results with the efficacy outcomes of a tafasitamab-lenalidomide combination therapy in the clinical trial MOR208C203 (L-MIND)

Key facts

Study ID

NCT04150328

Run by

MorphoSys AG

People needed

490

Starts

2019-04-12

Expected to finish

2020-08-25

Last updated by the study team

2022-08-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed diagnosis of DLBCL
• Relapsed/refractory to at least one previous systemic therapy for DLBCL
• Received at least one, but no more than three previous systemic regimens for the treatment of DLBCL, including at least one anti-CD20 containing therapy
• Received lenalidomide monotherapy for R/R DLBCL while being considered not eligible for an ASCT

You may not qualify if…

• CNS involvement by lymphoma
• Patients who received lenalidomide in combination with another anti-lymphoma therapy (including radiation)
• Previously treated with anti-CD19-targeted therapy or immunomodulatory drugs
• Patients who previously underwent allogeneic SCT
• Known simultaneous detection of MYC and BCL2 or BCL6 translocation according to FISH
• Patients with a history of other malignancies within 5 years prior to lenalidomide treatment start

Where it is running

• MorphoSys Research Site — St Louis, Missouri, United States
• MorphoSys Research Site — Manhasset, New York, United States
• MorphoSys Research Site — New York, New York, United States
• MorphoSys Research Site — Rochester, New York, United States
• MorphoSys Research Site — Dublin, Ohio, United States
• MorphoSys Research Site — Charleston, South Carolina, United States
• MorphoSys Research Site — Greenville, South Carolina, United States
• MorphoSys Research Site — Bordeaux, France
• MorphoSys Research Site — Le Mans, France
• MorphoSys Research Site — Lille, France
• MorphoSys Research Site — Lyon, France
• MorphoSys Research Site — Paris, France
• MorphoSys Research Site — Paris, France
• MorphoSys Research Site — Poitiers, France
• MorphoSys Research Site — Pontoise, France
• MorphoSys Research Site — Rouen, France
• MorphoSys Research Site — Toulouse, France
• MorphoSys Research Site — Tours, France
• MorphoSys Research Site — Aviano, Italy
• MorphoSys Research Site — Bergamo, Italy
• MorphoSys Research Site — Bologna, Italy
• MorphoSys Research Site — Brescia, Italy
• MorphoSys Research Site — Como, Italy
• MorphoSys Research Site — Cuneo, Italy
• MorphoSys Research Site — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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