Olive Oil Polyphenols and Cardiovascular Health Biomarkers

Running, not enrolling · Not applicable

Conditions studied: Healthy, Normal Weight, Overweight, Obese

In brief

The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation, and levels of gene expression.

Key facts

Study ID

NCT04149288

Run by

University of California, Davis

People needed

44

Starts

2021-10-06

Expected to finish

2026-08-22

Last updated by the study team

2026-01-29

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Generally healthy male and female subjects within the range of 20-45 years of age and BMI range of 18.5-29.9 kg/m2 for the healthy weight/overweight group and ≥ 30 kg/m2 for the obese group will be recruited.

You may not qualify if…

• Adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant or lactating women, women planning to become pregnant in the next two months and prisoners will be specifically excluded
• Documented chronic diseases including diabetes, thyroid disease, kidney disease, metabolic syndrome, active cancer, previous cardiovascular events, history of gastric bypass or other GI issues related to fat absorption
• History of dyslipidemia or abnormal blood glucose levels (total cholesterol >240 mg/dL, elevated fasting blood glucose levels >125 mg/dL)
• Allergy to olives, inability to tolerate gluten or multiple allergies/intolerances that would significantly limit food intake
• Smoker or living with a smoker, illicit drug use, consuming >1 alcoholic drink/day, vaporizer and/or electronic cigarette use
• Extreme dietary or exercise patterns
• Recent weight fluctuations (>10% in the last 6 months)
• Taking prescription lipid medications or supplements that may affect lipoprotein metabolism, >1 g of fish oil/day, antioxidant supplements, cannabidiol (CBD) oil
• Taking exogenous hormones (e.g. hormonal birth control)
• Poor venous access
• Unwillingness to comply with study protocol

Where it is running

• Ragle Human Nutrition Center — Davis, California, United States

Full record on ClinicalTrials.gov

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