Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)

Running, not enrolling · Phase 2

Conditions studied: Myasthenia Gravis, Generalized

In brief

This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis

Key facts

Study ID

NCT04146051

Run by

Cartesian Therapeutics

People needed

30

Starts

2019-12-04

Expected to finish

2026-03-31

Last updated by the study team

2025-05-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be at least 18 years of age.
• Patient must have Generalized Myasthenia Gravis at the time of screening.
• Concomitant immunosuppressive drugs must be deemed necessary by the investigator.
• Seronegative Patients are included

You may not qualify if…

• Major chronic illness that is not well managed at the time of study entry and in the opinion of the investigator may increase the risk to the patient.
• Patient is pregnant or lactating.

Where it is running

• Profound Research — Carlsbad, California, United States
• University of California Irvine — Irvine, California, United States
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
• SFM Clinical Research, LLC — Boca Raton, Florida, United States
• Neurology Associates, P.A. — Orlando, Florida, United States
• University of South Florida — Tampa, Florida, United States
• University of Augusta — Augusta, Georgia, United States
• University of Kansas Medical Center Research Institute — Kansas City, Kansas, United States
• Dent Neurologic Institute — Amherst, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• Oregon Health & Science University — Portland, Oregon, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Allegheny Health Network — Pittsburgh, Pennsylvania, United States
• Virginia Commonwealth University — Richmond, Virginia, United States
• University of Alberta — Edmonton, Alberta, Canada

Full record on ClinicalTrials.gov

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