House Dust Mite Allergy Trial In Children

Completed · Phase 3 · Has a placebo group

Conditions studied: Allergic Rhinitis Due to Dermatophagoides Farinae, Allergic Rhinitis Due to Dermatophagoides Pteronyssinus, Allergic Rhinitis Due to House Dust Mite

In brief

A research study of how house dust mite tablets work compared to placebo in children aged between 5 and 11 years and who have allergy to house dust mites (MATIC)

Key facts

Study ID

NCT04145219

Run by

ALK-Abelló A/S

People needed

1460

Starts

2019-10-12

Expected to finish

2023-04-21

Last updated by the study team

2024-06-12

Who can join

Age: 5 and older, up to 11. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects aged 5-11 years
• A clinical history of HDM AR/C (Allergic rhinitis/rhinoconjunctivitis) (with or without asthma) and with allergic rhinitis symptoms despite having received allergy pharmacotherapy during the previous year prior to screening
• Have a certain level of AR (Allergic rhinitis) symptoms on at least 8 of the last 14 days of the baseline period
• Use symptomatic medication for treatment of HDM allergic rhinitis during at least 8 of the last 14 days of the baseline period
• Positive skin prick test (SPT) and IgE (Immunoglobulin E) to D. pteronyssinus or D. farinae at screening
• Lung function ≥ 70% of predicted value

You may not qualify if…

• Sensitised and regularly exposed to perennial allergens
• Any nasal or pharyngeal condition that could interfere with the safety or efficacy evaluation
• Asthma requiring treatment with high dose of inhaled corticosteroid
• A relevant history of systemic allergic reaction

Where it is running

• California Allergy and Asthma Medical Group — Los Angeles, California, United States
• Allergy & Asthma Medical Group and Research Center, A P.C. — San Diego, California, United States
• Miami Clinical Research — Miami, Florida, United States
• Pensacola Research Consultants, Inc. d.b.a. Avanza Medical Research Center — Pensacola, Florida, United States
• Sarasota Clinical Research — Sarasota, Florida, United States
• GCP, Global Clinical Professionals — St. Petersburg, Florida, United States
• Aeroallergy Research Labs of Savannah, Inc. — Savannah, Georgia, United States
• Clinical Research Atlanta — Stockbridge, Georgia, United States
• Deaconess Clinic Allergy — Evansville, Indiana, United States
• PMG Research of McFarland Clinic — Ames, Iowa, United States
• Clinical Research Institute — Minneapolis, Minnesota, United States
• University of Missouri — Columbia, Missouri, United States
• Clinical Research of The Ozarks Inc — Warrensburg, Missouri, United States
• Summit Medical Group — Berkeley Heights, New Jersey, United States
• Allergy & Asthma Associates of Monmouth City — Little Silver, New Jersey, United States
• Allergy Partners of Western North Carolina — Asheville, North Carolina, United States
• The Children's Research Institute, Department of Pediatrics, University of North Carolina Children's Hospital — Chapel Hill, North Carolina, United States
• UNC Children's Raleigh — Raleigh, North Carolina, United States
• Bernstein Clinical Research Center — Cincinnati, Ohio, United States
• Allergy, Asthma & Clinical Research Center — Oklahoma City, Oklahoma, United States
• Oklahoma Institute of Allergy & Asthma Clinical Research, LLC — Oklahoma City, Oklahoma, United States
• Vital Prospects Clinical Research Institute, P.C. — Tulsa, Oklahoma, United States
• The Corvallis Clinic — Corvallis, Oregon, United States
• West Ashley office: Charleston Allergy & Asthma — Charleston, South Carolina, United States
• Allergy & Asthma Specialists Medical Group and Research Center — Huntington Beach, California, United States

Full record on ClinicalTrials.gov

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