Safety and Immunogenicity of mRNA-1653, a Combined Human Metapneumovirus (hMPV) and Parainfluenza Virus Type 3 (PIV3) Vaccine, in Healthy Adults, and Children 12 to 59 Months of Age With Serologic Evidence of Prior Exposure
Completed · Phase 1 · Has a placebo group
Conditions studied: Human Metapneumovirus and Human Parainfluenza Infection
In brief
This clinical study will assess the safety and immunogenicity of 2 dose levels of mRNA-1653, a combined human metapneumovirus and human parainfluenza virus type 3 vaccine, in healthy adults (18 to 49 years of age) and 2 dose levels in children (12 to 59 months of age) with serologic evidence of prior exposure. The safety profile of the adult cohort will permit enrollment of the pediatric cohort.
Key facts
- Study ID
- NCT04144348
- Run by
- ModernaTX, Inc.
- People needed
- 51
- Starts
- 2019-11-04
- Expected to finish
- 2022-12-20
- Last updated by the study team
- 2023-02-03
Who can join
Age: 1 and older, up to 49. Sex: any. Healthy volunteers: accepted.
Where it is running
- Central Research Associates Inc — Birmingham, Alabama, United States
- Meridian Clinical Research — Washington D.C., District of Columbia, United States
- Clinical Research Prime — Idaho Falls, Idaho, United States
- Heartland Research Associates LLC — El Dorado, Kansas, United States
- Heartland Research Associates LLC — Newton, Kansas, United States
- MedPharmics — Metairie, Louisiana, United States
- Meridian Clinical Research, LLC — Lincoln, Nebraska, United States
- Meridian Clinical Research — Norfolk, Nebraska, United States
- Meridian Clinical Research, LLC — Omaha, Nebraska, United States
- UHS Primary Care — Binghamton, New York, United States
- Child Healthcare Associates — Liverpool, New York, United States
- Child Healthcare Assoc. — Syracuse, New York, United States
- Duke Vaccine and Trials Unit — Durham, North Carolina, United States
- Ohio Pediatric Research Assn Inc — Dayton, Ohio, United States
- Sanford Children's Hospital — Sioux Falls, South Dakota, United States
- Crossroads Clinical Research — Corpus Christi, Texas, United States
- University of Texas Medical Branch (UTMB) — Galveston, Texas, United States
- Tekton Research Inc — San Antonio, Texas, United States
- Tanner Clinic — Layton, Utah, United States
Full record on ClinicalTrials.gov
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