Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

Running, not enrolling · Not applicable

Conditions studied: Schizophrenia

In brief

This project will conduct a confirmatory efficacy trial of two novel psychosocial interventions, Cognitive Enhancement Therapy and Enriched Supportive Therapy, for the treatment of persistent negative symptoms in schizophrenia.

Key facts

Study ID

NCT04143126

Run by

University of Pittsburgh

People needed

90

Starts

2019-10-01

Expected to finish

2027-06-30

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria will be evaluated longitudinally in a 4-week evaluation period. Patients will be included if they are outpatients and:
• are between 18-60 years of age;
• have a diagnosis of schizophrenia or schizoaffective disorder confirmed by the SCID;
• have a clinical history of persistent negative symptoms lasting at least 3 months as identified from the medical record;
• have observed persistent negative symptoms at the beginning and end of the 4-week evaluation period;
• have been stabilized on antipsychotic medication at the beginning and end of the 4-week evaluation period;
• have stabilized depressive symptoms at the beginning and end of the 4-week evaluation period;
• have mild or absent extrapyramidal symptoms at the beginning and end of the 4-week evaluation period;
• have had changes to their primary antipsychotic medication within the previous 3 months;
• have current IQ > 80; and
• are able to read (sixth grade level or higher) and speak fluent English. -

You may not qualify if…

• Exclusion criteria are intended to avoid likely treatment confounders and contraindications and include:
• the presence of organic brain syndrome;
• comorbid medical disorders producing cognitive impairment (e.g., mild brain injury, previous concussions with loss of consciousness);
• persistent suicidal or homicidal behavior;
• significant clinician-estimated medication non-adherence; and
• SCID-verified substance use disorder.

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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