LUMIERE on the FETUS
Recruiting now
Conditions studied: Pregnancy
In brief
Congenital anomalies are a major public health problem. They affect 2-3% of births, around 20,000 new cases per year in France, of which 15% are cared for in Ile de France. These congenital anomalies are a major cause of morbidity, infant mortality and disability. They are also a major cause of death during the infant period (22% of deaths during the first year of life: source CépiDC Inserm 2010). The detection, accurate diagnosis and accurate prognosis, particularly functional, of these congenital anomalies are still difficult in the current monitoring of pregnancy, which is based primarily on ultrasound. The use and development of modern imaging techniques is now essential to enable doctors to better see and better examine the fetus. Alongside ultrasound, Magnetic Resonance Imaging (MRI) is a technique that has undergone significant development in recent years. MRI must allow the effective anatomical and functional evaluation of the main fetal organs and could in particular be interesting in several situations in which it has not yet been sufficiently evaluated and is not yet performed in clinical routine.
Key facts
- Study ID
- NCT04142606
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 1500
- Starts
- 2019-12-06
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2025-11-20
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- patient ≥ 18 years
- Single or twin pregnancy
- gestational age≥ 16 WG and ≤ 36 WG based on cranio-caudal length (LCC) dating
- Collection of the patient's consent
You may not qualify if…
- contraindication to MRI
- multiple pregnancies > 2
- subsequent follow-up impossible
- maternal condition contraindicates continuation of pregnancy
- patient having to have an MRI examination as part of the normal clinical follow-up of her pregnancy (identified or strongly suspected echocardiographic abnormality on ultrasound, diaphragmatic dome hernia, CMV fetal infection, antecedent brain abnormality in siblings, STT operated)
Where it is running
- Necker - Enfants Malades Hospital — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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