Skeletal Muscle Energetics and Fatiguability in Older Individuals

Recruiting now

Conditions studied: HIV, HIV Infections

In brief

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Key facts

Study ID

NCT04142047

Run by

Johns Hopkins University

People needed

200

Starts

2019-09-05

Expected to finish

2027-07-01

Last updated by the study team

2026-06-08

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants who are >= 60 years of age
• HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (<100 copies).
• HIV serostatus negative participants

You may not qualify if…

• Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
• Contraindications to MRI
• Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
• Significant lower extremity peripheral vascular disease.
• Weight greater than 350 lbs
• Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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