Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease
Recruiting now
Conditions studied: Non-Alcoholic Fatty Liver Disease
In brief
To identify key characteristics of the tissue resident and peripherally circulating immune-phenotype in addition to blood markers, metabolic profile, faecal and oral microbiota in non-alcoholic fatty liver disease
Key facts
- Study ID
- NCT04141592
- Run by
- Queen Mary University of London
- People needed
- 153
- Starts
- 2019-03-05
- Expected to finish
- 2026-07-31
- Last updated by the study team
- 2026-06-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Confirmed non-alcoholic Fatty liver disease (diagnosed clinically, radiologically or histologically)
- If diabetic, Diagnosed with Type 2 Diabetes Mellitus
- OR
- Healthy Control: no diagnosis of any liver condition including NAFLD
- o NAFLD excluded by Fibroscan Controlled Attenuation Parameter (CAP) score of <222 dB/m
You may not qualify if…
- Unwilling or unable to give informed consent
- Type 1 Diabetes Mellitus
- Other form of liver disease (other than NAFLD)
- o Viral hepatitis, Auto-immune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis, haemochromatosis, Sarcoidosis, cystic fibrosis, sickle cell disease
- Taking medication associated with liver dysfunction (except methotrexate)
- Auto-immune disease which in the investigator's opinion may confound immune profiling
- Concomitant immunosuppressive medications (except methotrexate, short course oral steroids or inhaled corticosteroids)
- Currently pregnant
- Any major organ transplant (excluding corneal or hair transplant)
- Regular alcohol intake greater than 14 units a week for female participants and 21 units a week for male participants
Where it is running
- Homerton University Hospital Foundation Trust — London, Greater London, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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