Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms

Recruiting now · Phase 2

Conditions studied: Cerebral Aneurysm

In brief

The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.

Key facts

Study ID

NCT04141020

Run by

University of Miami

People needed

80

Starts

2021-10-27

Expected to finish

2026-11-01

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing one of the following procedures at Jackson Memorial Hospital:
• Clipping of an unruptured cerebral artery aneurysm
• Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling)
• ≥ 18 years of age
• Willing and able to give informed consent

You may not qualify if…

• Subjects meeting any of the following criteria will be excluded:
• Dissecting, traumatic, or mycotic brain aneurysm.
• Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test.
• Women who are breastfeeding.
• Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol.
• Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency.
• Patient with renal or liver failure
• Interstitial pneumonitis
• History of lymphoma
• History of skin cancer
• Hypersensitivity to sirolimus
• Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention.

Where it is running

• University of Miami — Miami, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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