VItamin C in Thermal injuRY: The VICToRY Trial

Paused · Phase 3 · Has a placebo group

Conditions studied: Shock, Thermal Burn

In brief

This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.

Key facts

Study ID

NCT04138394

Run by

Clinical Evaluation Research Unit at Kingston General Hospital

People needed

666

Starts

2020-07-24

Expected to finish

2026-03-31

Last updated by the study team

2026-04-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Deep 2nd and/or 3rd degree burns requiring skin grafting
• Minimum burn size of ≥ 20% Total Body Surface Area (TBSA)

You may not qualify if…

• >24 hours from admission to participating hospital to consent.
• Patients admitted to burn unit >24 from injury or accident.
• Patients who are moribund (not expected to survive the next 72 hours).
• Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating.
• Enrollment in another industry sponsored ICU intervention study.
• Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed).
• Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Recent history of kidney stones (within the last year).
• Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.

Where it is running

• Arizona Burn Center Valleywise Health — Phoenix, Arizona, United States
• Bridgeport Hospital — Bridgeport, Connecticut, United States
• MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
• The University of Chicago Medical Center — Chicago, Illinois, United States
• University of Iowa Hospitals & Clinics — Iowa City, Iowa, United States
• Mercy Hospital St. Louis — St Louis, Missouri, United States
• The Ohio State University Medical Center — Ohio City, Ohio, United States
• University of Texas Health Science Center - Houston — Houston, Texas, United States
• Harborview Medical Center - Seattle — Seattle, Washington, United States
• Ascension Columbia St. Mary's — Milwaukee, Wisconsin, United States
• Grand Hopital de Charleroi — Charleroi, Hainaut, Belgium
• Ghent University Hospital — Ghent, Oost Vlaanderen, Belgium
• Belgium Military Hospital, Military Hospital — Brussels, Belgium
• Centre Hospitalier Universitaire de Liege — Liège, Belgium
• QEII Health Sciences Centre — Halifax, Nova Scotia, Canada
• Hamilton General Hospital, Hamilton Health Sciences Corporation — Hamilton, Ontario, Canada
• Sunnybrook Health Sciences Centre, Ross Tilley Burn Centre — Toronto, Ontario, Canada
• Centre de recherche du CHUM — Montreal, Quebec, Canada
• CHU de Québec-Université Laval, Hôpital de l'Enfant-Jésus — Québec, Quebec, Canada
• Hospital San Juan de Dios — San José, Provincia de San José, Costa Rica
• BG Klinik Tübingen — Tübingen, Baden-Wurttemberg, Germany
• Klinikum St. George — Leipzig, Saxony, Germany
• RWTH Aachen University, Aachen — Aachen, Germany
• Merheim Medical Center, Hospitals of Cologne — Cologne, Germany
• Berufsgenossenschaftliche Unfallklinik Ludwigshafen — Ludwigshafen, Germany

Full record on ClinicalTrials.gov

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