Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer
Running, not enrolling · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Stage II Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8
In brief
This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent peripheral neuropathy.
Key facts
- Study ID
- NCT04137107
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 220
- Starts
- 2020-06-17
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-01-26
Who can join
Age: 25 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of South Alabama Mitchell Cancer Institute — Mobile, Alabama, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
- Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Kingman Regional Medical Center — Kingman, Arizona, United States
- Cancer Center at Saint Joseph's — Phoenix, Arizona, United States
- Mercy Hospital Fort Smith — Fort Smith, Arkansas, United States
- CHI Saint Vincent Cancer Center Hot Springs — Hot Springs, Arkansas, United States
- CARTI Cancer Center — Little Rock, Arkansas, United States
- John L McClellan Memorial Veterans Hospital — Little Rock, Arkansas, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande, California, United States
- PCR Oncology — Arroyo Grande, California, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- Mercy Cancer Center - Carmichael — Carmichael, California, United States
- Mercy San Juan Medical Center — Carmichael, California, United States
- Adventist Health Cancer Care Center Chico — Chico, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Epic Care-Dublin — Dublin, California, United States
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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