The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy

Completed · Phase 3

Conditions studied: Proliferative Vitreoretinopathy

In brief

The GUARD Trial is a multi-center, randomized, controlled, adaptive Phase 3 clinical trial of repeated intravitreal injections of ADX-2191 versus standard-of-care for the prevention of proliferative vitreoretinopathy.

Key facts

Study ID

NCT04136366

Run by

Aldeyra Therapeutics, Inc.

People needed

106

Starts

2019-11-15

Expected to finish

2022-06-14

Last updated by the study team

2025-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is 18 years or older of any gender or race
• Subject is undergoing pars plana vitrectomy due to recurrent retinal detachment due to proliferative vitreoretinopathy or open globe injury
• Subject is willing and able to provide written informed consent, comply with clinical trial procedures, and return for all clinical trial visits
• Subjects of childbearing potential must agree to use two forms of birth control for the duration of the clinical trial

You may not qualify if…

• History of severe non-proliferative or proliferative diabetic retinopathy
• Other planned eye surgery during the course of the trial
• Participation in a clinical trial with an investigational medicinal product or investigational device within 90 days of subject enrollment

Where it is running

• Retinal Consultants of Arizona — Phoenix, Arizona, United States
• University of California Los Angeles — Los Angeles, California, United States
• Florida Retina Institute — Orlando, Florida, United States
• Bascom Palmer Eye Institute — Palm Beach Gardens, Florida, United States
• Emory Eye Center — Atlanta, Georgia, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Illinois Retina Associates — Joliet, Illinois, United States
• University of Iowa — Iowa City, Iowa, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• Massachusetts Eye and Ear — Boston, Massachusetts, United States
• New England Retina Consultants — Springfield, Massachusetts, United States
• Kresge Eye Institute — Detroit, Michigan, United States
• Associated Retinal Consultants — Royal Oak, Michigan, United States
• Vitreo-Retinal Surgery — Minneapolis, Minnesota, United States
• Mayo Clinic Ophthalmology — Rochester, Minnesota, United States
• The Retina Institute — St Louis, Missouri, United States
• Long Island VitreoRetinal Consultants — Forest Hills, New York, United States
• Duke Health Center — Durham, North Carolina, United States
• OHSU Casey Eye Institute — Portland, Oregon, United States
• Mid Atlantic Retina — Philadelphia, Pennsylvania, United States
• Retina Consultants of Houston — Houston, Texas, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.