NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Completed · Phase 3
Conditions studied: Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
In brief
The main objective of this study was to evaluate the efficacy of eplontersen as compared with the historical control of the placebo cohort in the NEURO-TTR trial (NCT01737398/2012-001831-30), in subjects with hereditary transthyretin-mediated amyloidosis polyneuropathy (hATTR-PN). For more information, please visit http://www.neuro-ttransform.com/.
Key facts
- Study ID
- NCT04136184
- Run by
- Ionis Pharmaceuticals, Inc.
- People needed
- 168
- Starts
- 2019-12-11
- Expected to finish
- 2023-07-12
- Last updated by the study team
- 2024-12-13
Who can join
Age: 18 and older, up to 82. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic - Arizona — Scottsdale, Arizona, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Indiana University School of Medicine - Indianapolis — Indianapolis, Indiana, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- Johns Hopkins University Neurology Research Office — Baltimore, Maryland, United States
- Boston University School of Medicine — Boston, Massachusetts, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- The Neurological Institute of New York — New York, New York, United States
- University of North Carolina Hospitals - Neurology Clinic — Chapel Hill, North Carolina, United States
- Oregon Health and Science University — Portland, Oregon, United States
- Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States
- University of Washington Medical Center — Seattle, Washington, United States
- Hospital Italiano de Buenos Aires — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
- Hospital El Cruce — San Juan Bautista, Buenos Aires, Argentina
- STAT Research — Buenos Aires, Argentina
- Instituto Fleni — Buenos Aires, Argentina
- Perron Institute for Neurological and Translational Science — Nedlands, Western Australia, Australia
- Instituto de Neurologia de Curitiba — Curitiba, Paraná, Brazil
- Universidade Estadual de Campinas — Campinas, Brazil
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto — Ribeirão Preto, Brazil
- Hospital Universitário Clementino Fraga Filho — Rio de Janeiro, Brazil
- Associação de Assistência à Criança Deficiente - Unidade Lar Escola — São Paulo, Brazil
- Toronto General Hospital — Toronto, Ontario, Canada
- The Cyprus Institute of Neurology and Genetics — Égkomi, Cyprus
- Centre Hospitalier Universitaire de Toulouse — Toulouse, Haute-Garonne, France
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.