Alpha-1 Blockade for Alcohol Use Disorder (AUD)

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Alcohol Use Disorder (AUD)

In brief

The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.

Key facts

Study ID

NCT04135846

Run by

Brown University

People needed

184

Starts

2019-12-19

Expected to finish

2026-08-31

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, 18 years of age
• Meet the DSM-5 criteria for AUD
• Desire to reduce or quit alcohol drinking
• Breath alcohol (BrAC) = 0.00 at each visit
• In good health as confirmed by medical history, physical examination and lab tests
• Willing to adhere to the study procedures
• Understand informed consent and questionnaires in English at an 8th grade level

You may not qualify if…

• Women who are breastfeeding or /positive urine test for pregnancy
• CrCl<60mL/min
• Suicide attempt in the last three months
• Current diagnosis of other substance disorder other than nicotine as assessed by self-report and urine toxicology screen at baseline
• Current use of medication that may interact with doxazosin and/or yohimbine
• History of allergy to any alpha receptor blockers
• Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) score ≥ 8
• Treatment with disulfiram, naltrexone, acamprosate, topiramate within 1 month prior to screening
• Treatment with any alpha-blocker
• Individuals with cardiac heat failure (CHF), as assessed by the medical history, the physical exam and the ECG.
• Baseline hypotension defined as BP reading lower than 90/60 mmHg
• Use of phosphodiesterase inhibitors (PDE5) erectile dysfunction medication

Where it is running

• Brown University — Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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