The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration

Withdrawn before enrolling · Not applicable

Conditions studied: Back Pain, Intervertebral Disc Degeneration

In brief

The purpose of this research study is to examine the effects of physical therapy on the spinal discs. Back pain is the number one cause of disability in the US, and the spine is the most common location of chronic pain in Veterans. Physical therapy is often very effective at improving patients' back pain, but it does not work for everyone, and it is not understood how physical therapy alters the tissues within the spine. With this research the investigators hope to learn if the investigative team can measure changes to the spinal discs on MRI scans that might predict if a patient's back pain will improve with physical therapy or not.

Key facts

Study ID

NCT04134910

Run by

VA Office of Research and Development

People needed

0

Starts

2025-02-03

Expected to finish

2025-02-03

Last updated by the study team

2026-02-27

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current activity limiting low back pain
• With symptoms of any duration
• With or without symptoms extending distal to the buttocks
• Medically stable
• Candidate for physical therapy

You may not qualify if…

• Documented history of prior spinal surgery
• Contraindications to MRI including:
• claustrophobia
• pregnancy
• implanted electronic devices
• pacemakers, cochlear implant, insulin pumps, etc
• metallic foreign bodies
• i.e. shrapnel
• documented history of contraindications to gadodiamide (Omniscan) administration:
• chronic severe kidney disease
• acute kidney injury
• impaired elimination of gadolinium based contrast agents
• pre-existing renal insufficiency
• a prior hypersensitivity reaction to MRI contrast

Where it is running

• Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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