Improving Outcomes in Cardiac Arrest With Inhaled Nitric Oxide
Status unconfirmed · Early Phase 1
Conditions studied: Cardiac Arrest
In brief
Sudden cardiac arrest (CA) is a leading cause of death worldwide. CA claims the lives of an estimated 300,000 Americans each year. Despite advances in cardiopulmonary resuscitation (CPR) methods, only approximately 10% of adults with CA survive to hospital discharge, and up to 60% of survivors have moderate to severe cognitive deficits 3 months after resuscitation. Most of the immediate and post-CA mortality and morbidity are caused by global ischemic brain injury. The goal of this grant application is to test the hypothesis that resuscitation from cardiac arrest can be improved by improving cerebral oxygenation through inhalation of nitric oxide. This strategy will also improve the chances of return of spontaneous circulation (ROSC), improve short-term survival and neurologic outcome.
Key facts
- Study ID
- NCT04134078
- Run by
- Stony Brook University
- People needed
- 100
- Starts
- 2016-08-01
- Expected to finish
- 2022-07-01
- Last updated by the study team
- 2019-10-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years and above
- In-hospital cardiac arrest as defined by cessation of heartbeat
- Presence of Endotracheal Tube
You may not qualify if…
- Age below 18 years
- Absence of Endotracheal Tube
- Patients with out-of-hospital cardiac arrest
- Patients involved in trauma and/or patients in the SICU or CTICU
- Preexisting intra-cerebral lesions such as any head injury (old or new), brain hematoma, cerebral hemorrhage or known frontal lobe disorders such as tumors
- Any patient with a terminal condition that cannot be treated (specifically any terminal malignancy, end stage lung fibrosis, chronic heart failure with an ejection fraction <20%)
- Patients with do not resuscitate and/or do not intubate (DNR/DNI) status
- Therapeutic window has passed
Where it is running
- Stony Brook University — South Setauket, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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