ICONIC: Improving Outcomes Through Collaboration in OsteosarComa
Recruiting now
Conditions studied: Osteosarcoma
In brief
There has been little improvement in outcome for patients with osteosarcoma (OS) over the last 20 years. There have been only a few clinical trials of new treatments and no major new therapies introduced recently. This is in part because there is no good understanding of the biology of osteosarcoma, but also trials have only included subgroups of patients. The more that is understood about how and why osteosarcoma arises and grows the better clinicians will be able to decide what treatments are most likely to work best. The purpose of this project is to collect high quality clinical data about patients of all ages with osteosarcoma, such as information about the size of the disease, how it was diagnosed and where it is at diagnosis, what treatments were given and how the disease responded the treatments. Blood and tissue samples will also be collected for analysis in research laboratories. By looking at the results of the laboratory findings and the clinical data together, the questions will start to be answered about why osteosarcomas arise and grow, what makes it spread, and why some patients respond to treatment better than others. As time goes on, this information is planned to be used to develop clinical trials of new treatments. Alongside this, the aim is to find out more about how osteosarcoma and its treatments affect the lives of those living with this disease. This information will help provide the most appropriate care and support that will meet the needs of each patient. Ultimately, the aim is to improve the care and treatment of osteosarcoma patients so that they may live longer and better lives.
Key facts
- Study ID
- NCT04132895
- Run by
- University College, London
- People needed
- 300
- Starts
- 2019-10-25
- Expected to finish
- 2027-01-31
- Last updated by the study team
- 2024-08-02
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- New histological diagnosis of osteosarcoma or in the absence of osteoid seen on biopsy, pathology and imaging supportive of a diagnosis of osteosarcoma. (It is well recognised that some patients may present with features suggestive of osteosarcoma (under 40 years, radiological abnormality compatible) but in whom no osteoid is detected in needle biopsy. Although categorised as spindle cell tumour of bone, such patients are usually treated in an identical approach to osteosarcoma. A definite diagnosis of osteosarcoma is then often possible after surgery when the entire resection specimen is available.)
- Written informed consent of patient and/or parent/legal guardian.
You may not qualify if…
- Diagnosis more than four months prior to registration.
Where it is running
- University College Hospitals London NHS Foundation Trust — London, Greater London, United Kingdom (enrolling)
- NHS Grampian Health Board — Aberdeen, United Kingdom (enrolling)
- Birmingham Women's and Childrens NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
- The Royal Orthopaedic Hospital NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
- University Hospitals Birmingham NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
- Cambridge University Hospitals NHS Foundation Trust — Cambridge, United Kingdom (enrolling)
- Cardiff and Vale University LHB — Cardiff, United Kingdom (enrolling)
- NHS Lothian Health Board — Edinburgh, United Kingdom (enrolling)
- NHS Greater Glasgow and Clyde Health Board — Glasgow, United Kingdom (enrolling)
- Leeds Teaching Hospitals NHS Trust — Leeds, United Kingdom (enrolling)
- University Hospitals of Leicester NHS Trust — Leicester, United Kingdom (enrolling)
- Alder Hey Children's NHS Foundation Trust — Liverpool, United Kingdom (enrolling)
- The Clatterbridge Cancer Centre NHS Foundation Trust — Liverpool, United Kingdom (enrolling)
- Manchester University NHS Foundation Trust — Manchester, United Kingdom (enrolling)
- The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)
- The Newcastle upon Tyne Hospitals NHS Foundation Trust — Newcastle, United Kingdom (enrolling)
- Nottingham University Hospitals NHS Trust — Nottingham, United Kingdom (enrolling)
- The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust — Oswestry, United Kingdom (enrolling)
- Oxford University Hospitals NHS Foundation Trust — Oxford, United Kingdom (enrolling)
- Sheffield Children's NHS Foundation Trust — Sheffield, United Kingdom (enrolling)
- Sheffield Teaching Hospitals NHS Foundation Trust — Sheffield, United Kingdom (enrolling)
- University Hospital Southampton NHS Foundation Trust — Southampton, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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