Opioid and Pain Cognition
Completed · Not applicable
Conditions studied: Pain
In brief
The proposed research will provide foundational research to develop this low-burden behavioral intervention that can potentially improve outcomes of OUD. The Specific Aims of the proposal include conducting a pilot randomized controlled trial with post-intervention and 3 month follow up to evaluate feasibility, acceptability, and preliminary effectiveness of CBM task for opioid and pain cues (Aim 1), examine naturalistic assessment of opioid craving and pain intensity/interference (Aim 2), and conduct qualitative analysis of Veterans experiences of adjunctive treatment in MAT clinic and perceptions of CBM as an intervention (Aim 3). Male and female Veterans meeting DSM5 criteria for OUD (N=60) currently on MAT will be randomly assigned to 4 weeks of CBM for opioid and pain cues or control (standard attentional bias). CBM/control tasks will be administered during weekly MAT clinic appointments and opioid craving and pain intensity/interference will be randomly assessed during the day using a mobile device. Post-intervention, Veterans will be invited to participate in a digitally recorded semi-structured interview for qualitative assessment of CBM and treatment adjunctive to MAT. MAT outcomes (urine toxicology screens, MAT appointments) will also be measured at 3-month follow up. The current study will elucidate dynamic relationships between attention to opioid and pain cues and whether modifying attention can reduce risk factors associated with treatment failure. If successful, with its low patient and provider burden, CBM could be readily incorporated in research and clinical practice as an adjunctive treatment for OUD.
Key facts
- Study ID
- NCT04132609
- Run by
- Yale University
- People needed
- 20
- Starts
- 2019-02-01
- Expected to finish
- 2021-03-01
- Last updated by the study team
- 2021-06-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Veterans that meet DSM5 criteria for OUD
- Be engaged in Methadone Maintained Program
- Report clinically significant past-week pain intensity (i.e., at least moderate pain severity)
You may not qualify if…
- The inability to read, write and speak English
- Active suicidal ideation
- Diagnosis of psychotic disorder
- Use of drugs that interact negatively with MAT (e.g. benzodiazepines), and
- uncorrected defective vision, which would interfere completing the dot probe task
Where it is running
- Veteran Affairs Hospital — West Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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