Promotion of Weight Management

Running, not enrolling · Not applicable

Conditions studied: Overweight

In brief

The identification of intermittent fasting as an alternative method to traditional weight maintenance protocols could have a significant impact on preventing body weight regain common after successful weight loss, and potentially lead to a reduction in pharmaceutical and clinical costs related to the care of overweight and obese adults.

Key facts

Study ID

NCT04131647

Run by

VA Office of Research and Development

People needed

175

Starts

2021-03-01

Expected to finish

2026-10-01

Last updated by the study team

2026-01-12

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veteran
• 50-75 years of age
• BMI: 25-40 kg/m2
• Postmenopausal status for women

You may not qualify if…

• Uncontrolled diabetes (HbA1c >10% or the current use of insulin)
• Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
• Active inflammatory, autoimmune, infectious, hepatic, gastrointestinal, malignant, and psychiatric disease
• Weight change within the past month of >5 kg
• Self-reported alcohol or drug abuse
• Anti-coagulant medication for muscle biopsies only Impaired renal function (creatinine > 1.5 mg/dl) History or evidence of serious liver disease (LFTs > 2.5 x WNL)

Where it is running

• Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States
• South Texas Health Care System, San Antonio, TX — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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