Personalized Swiss Sepsis Study

Recruiting now

Conditions studied: Sepsis

In brief

This multi-center study is to focus on patients with sepsis in Intensive Care Units (ICUs) in order to better understand the complex host-pathogen interaction and clinical heterogeneity associated with sepsis. Understanding this heterogeneity may allow the development of novel diagnostic approaches. Data from patients will be analyzed using state-of-the art analytical algorithms for biomarker discovery including machine learning and multidimensional mathematical modelling to explore the large datasets generated. In order to discover digital biomarkers for the study endpoints a case-control study design will be used to compare data patterns from patients with sepsis (cases) and those without sepsis (controls).

Key facts

Study ID

NCT04130789

Run by

University Hospital, Basel, Switzerland

People needed

17500

Starts

2019-11-15

Expected to finish

2025-12-01

Last updated by the study team

2025-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients admitted to an ICU on a Swiss University Hospital.
• Patients expected to stay at least 24h on the ICU
• Inclusion Criteria (cases)
• Present at admission to ICU or subsequent development of sepsis 3.0 criteria
• Inclusion Criteria (controls)
• Patients not fulfilling sepsis definition during the ICU stay

You may not qualify if…

• Decline of general consent or any other negative statement against using data for research.
• Patients with a clear elective stay on the ICUs.

Where it is running

• Clinical Microbiology, University Hospital Basel — Basel, Switzerland (enrolling)
• Infectious Diseases and Hospital Epidemiology, University Hospital Basel — Basel, Switzerland (enrolling)
• Medical Intensive Care Unit; University Hospital Basel — Basel, Switzerland (enrolling)
• Surgical Intensive Care Unit, University Hospital Basel — Basel, Switzerland (enrolling)
• Institute for Infectious Diseases, University of Bern — Bern, Switzerland (enrolling)
• Division Infectious Diseases, University Hospital Bern — Bern, Switzerland (enrolling)
• Intensive Care Medicine, University Hospital Bern — Bern, Switzerland (enrolling)
• Division Bacteriology Laboratory, University Hospital Geneva — Geneva, Switzerland (enrolling)
• Division Infectious Diseases, University Hospital Geneva — Geneva, Switzerland (enrolling)
• Intensive Care Medicine, University Hospital Geneva — Geneva, Switzerland (enrolling)
• Division Intensive Care Medicine, University Hospital Lausanne — Lausanne, Switzerland (enrolling)
• Institute of Microbiology, University Hospital Lausanne — Lausanne, Switzerland (enrolling)
• Service Infectious Diseases, University Hospital Lausanne — Lausanne, Switzerland (enrolling)
• Institute for Medical Microbiology, University Hospital Zurich — Zurich, Switzerland
• Division Infectious Diseases, University Hospital Zurich — Zurich, Switzerland
• Institute for Intensive Medicine, University Hospital Zurich — Zurich, Switzerland

Full record on ClinicalTrials.gov

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