Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
Completed
Conditions studied: Atrial Fibrillation
In brief
This is a prospective, observational study that will examine endothelial dysfunction in atrial fibrillation before and after treatment with anti-arrhythmic agents and the extent to which baseline endothelial dysfunction improves after treatment.
Key facts
- Study ID
- NCT04128878
- Run by
- Samir Saba
- People needed
- 12
- Starts
- 2019-05-01
- Expected to finish
- 2020-12-31
- Last updated by the study team
- 2021-01-14
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients (18-75 years of age) with paroxysmal or persistent atrial fibrillation
- Patients who recovered from prior tachycardia induced cardiomyopathy will be allowed to enroll in the study.
You may not qualify if…
- Exclusion criteria will include:
- age >75 years
- history of cardiomyopathy
- history of severe cardiac valvular disease
- history of coronary artery disease
- pulmonary artery hypertension
- congenital heart disease
- history of stroke
- chronic hypoxia
- recent worsening or flare up of obstructive or restrictive lung disease
- liver cirrhosis
- stage three or worse chronic kidney disease
- any major trauma or surgery within the preceding 3 months
- uncontrolled hyperthyroidism
- uncontrolled hypertension
- uncontrolled diabetes mellitus
- active malignancy
- poorly controlled connective tissue disease
- any acute or chronic inflammatory or infectious disease
- Patients who are already on class I or class III antiarrhythmic agents will be excluded from the study
- Patients on non-dihydropyridine calcium channel blockers and beta blockers will not be excluded from the study, as these agents are not considered anti-arrhythmics and are not hypothesized to affect endothelial function.
Where it is running
- University of Pittsburgh Medical Center - Presbyterian University Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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