Impacts of Aronia on Inflammation and the Gut Microbiome

Completed · Not applicable · Has a placebo group

Conditions studied: Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity

In brief

The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases. While an elevation in immune signals in the systemic circulation is commonly attributed to adipose tissue, inflammation is not present in all obese individuals. Adipose tissue must become inflamed, and the inflammation trigger may come from other sources. Microorganisms (microbiome), host tissues, and immune cells residing in the gastrointestinal tract (GIT) are a key source of pro-inflammatory signals that may cause the host organism to become inflamed. Anthocyanins are bioactive compounds with established anti-inflammatory and microbiome altering properties. We hypothesize that the GIT microbiome is a key determinant of host inflammation than can be manipulated by anthocyanins-rich berries to lower inflammation. We assembled a cohort of individuals, characterized their GIT microbiome and performed anthropometric measurements, basal measures of metabolism and metabolic health, and triglyceridemic, metabolomic, and inflammation responses to a high-fat meal challenge.

Key facts

Study ID

NCT04128839

Run by

Montana State University

People needed

40

Starts

2019-04-27

Expected to finish

2021-12-27

Last updated by the study team

2024-01-16

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI 28-35 kg/m\^2

You may not qualify if…

• Antibiotics up to 90 days prior to enrollment
• Anti-inflammatory medications
• Allergy or intolerance to wheat or dairy
• Hormone-based birth control (with exception of intrauterine device)
• Pregnant
• Heart disease
• Other health conditions or concerns that may interfere with study participation

Where it is running

• Montana State University — Bozeman, Montana, United States

Full record on ClinicalTrials.gov

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