Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
Recruiting now
Conditions studied: Coronary Artery Stenosis
In brief
The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.
Key facts
- Study ID
- NCT04126148
- Run by
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- People needed
- 350
- Starts
- 2019-07-04
- Expected to finish
- 2024-12-01
- Last updated by the study team
- 2024-10-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Participants
- Age: > 40y
- No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.
- CAD Patients
- Age > 18 y
- Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.
You may not qualify if…
- ALL participants:
- General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
- Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
- Regular nicotine consumption during the last 6 months.
- Patients only
- Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
- Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
- Previous myocardial infarction within 1 month
- Clinically unstable condition
- Significant or uncontrolled arrhythmia
Where it is running
- McGill University Health Center — Montreal, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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