Comparative Imaging Assessment of Valvular Heart Disease

Recruiting now

Conditions studied: Valve Heart Disease, Aortic Stenosis, Aortic Regurgitation

In brief

The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.

Key facts

Study ID

NCT04126018

Run by

The Cleveland Clinic

People needed

200

Starts

2019-08-23

Expected to finish

2027-12-31

Last updated by the study team

2026-01-13

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-90 years of age
• Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam.
• Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction

You may not qualify if…

• Acute traumatic cardiac injury
• Aortic dissection or aortic root rupture
• Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD
• Presence of A-V fistula or intracardiac shunts
• Any contraindications to CMR
• Moderate or severe dysfunction in multiple valves
• Patients with significant claustrophobia

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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