Influence of Exercise on the Gut Microbiome of Overweight and Obese Adults With Prediabetes

Stopped early · Not applicable

Conditions studied: PreDiabetes

In brief

Purpose: The investigators propose a 20-participant randomized 2-arm parallel trial with a delayed-intervention control examining how 8 weeks of moderate-intensity walking exercise alters the gut microbiome, short chain fatty acid (SCFA)-producing taxa, and the cardiometabolic profile and body weight of individuals who are overweight or obese and have prediabetes (PreD). Aim 1: Examine and compare exercise-related shifts in the gut microbiome of individuals with PreD. Aim 2: Examine and compare exercise-related changes in SCFA-producing taxa. Exploratory Aim: Examine what percentage of the exercise-related changes observed in participants' gut microbiome and SCFA-producing taxa mediate changes in their cardiometabolic profile and body weight.

Key facts

Study ID

NCT04124354

Run by

University of Minnesota

People needed

4

Starts

2020-02-10

Expected to finish

2020-08-31

Last updated by the study team

2021-07-13

Who can join

Age: 30 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Classified as overweight or obese with BMI 25.0-39.9 kg/m2
• Diagnosis of prediabetes as classified by a fasted blood glucose of 100 - 125 mg/dL, 2-hour oral glucose tolerance test of 140 - 199 mg/dL, or HbA1C level of 5.7% - 6.5%
• Currently engaged in < 150 minutes/week of physical activity-confirmed via the Modifiable Activity Questionnaire

You may not qualify if…

• Individuals with contraindications to exercise participation as assessed by the Physical Activity Readiness Questionnaire
• Self-reported physical/mental disabilities or gastrointestinal conditions
• Antibiotic usage within the last 45 days

Where it is running

• Epidemiology Clinical Research Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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