Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis

Completed · Not applicable

Conditions studied: Myocardial Infarction

In brief

The purpose of this study is to look at the link between emotional stress and heart disease in men and women. Taking part in this study involves one clinic visit, one week of at home monitoring, and follow up phone calls every 6 months for 3 years.

Key facts

Study ID

NCT04123197

Run by

Emory University

People needed

306

Starts

2020-02-28

Expected to finish

2025-05-31

Last updated by the study team

2026-07-24

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of documented MI within the past 8 months
• Age ≤60 at the time of MI

You may not qualify if…

• History of unstable angina, MI, or decompensated heart failure in the past month
• Patients deemed to be unsafe to hold anti-ischemic medications before testing (it is standard protocol to hold these meds before imaging studies)
• Systolic blood pressure (SBP) >180 mm Hg or diastolic blood pressure (DBP) >110 mm Hg on the day of the test
• Alcohol or substance abuse (past year), or severe psychiatric disorder other than major depression
• Other serious medical disorders that may interfere with the study results
• Postmenopausal hormone therapy (past 3 months)
• Current psychotropic medications (past month) except anti-depressants
• Pregnancy or breastfeeding (all women will receive a pregnancy test)
• Severe aortic stenosis
• Weight ≥ 360 pounds and/or body mass index (BMI) of 40 or greater (weight limit of the SPECT imaging table)

Where it is running

• Emory University Hospital — Atlanta, Georgia, United States
• Grady Health System — Atlanta, Georgia, United States
• The Emory Clinic — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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