DNA Repair Activity in the Skin of Day and Night Shift Workers

Recruiting now · Not applicable

Conditions studied: Skin Cancer

In brief

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

Key facts

Study ID

NCT04122456

Run by

Wright State University

People needed

48

Starts

2022-12-07

Expected to finish

2027-12-01

Last updated by the study team

2026-07-17

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male/Female
• Fair skin (Fitzpatrick types I and II)
• Age 18 to 40
• Able to comprehend procedures/risks
• Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.

You may not qualify if…

• Known photosensitivity
• Currently on photosensitizing medications
• Diabetes Mellitus
• On any hormonal agents (e.g., birth control pills)
• History of abnormal scarring
• History of skin infections
• History of skin cancers
• History of sleep disorders such as sleep apnea or insomnia
• Known allergy to lidocaine local anesthetic
• Pregnancy or nursing
• Other serious health issues

Where it is running

• Wright State Physicians — Fairborn, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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