Growth Hormone Replacement Therapy for Retried Professional Football Players

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: TBI (Traumatic Brain Injury), Concussion, Brain, Sport Injury, Anterior Pituitary Hyposecretion Syndrome, Hypopituitarism, Growth Hormone Deficiency

In brief

This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).

Key facts

Study ID

NCT04121780

Run by

Center for Neurological Studies

People needed

42

Starts

2019-10-08

Expected to finish

2026-09-01

Last updated by the study team

2023-02-08

Who can join

Age: 18 and older, up to 76. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• The subject is willing to provide a signed and dated informed consent indicating that he understands the purpose and procedures required for the study and is willing to participate in the study.
• Former NFL player
• At least one year since retirement from football
• Less than 76 years of age
• Diagnosis of GHD on clinical grounds by a neurologist and an endocrinologist GHD

You may not qualify if…

• History of pre-existing brain disease other than concussion or TBI
• History of a premorbid disabling condition that interferes with outcome assessments
• Contraindication to GH therapy
• Type I and II Diabetes mellitus
• Active malignant disease
• Acute critical illness, heart failure, or acute respiratory failure
• Subjects who are deficient in cortisol, testosterone or thyroid at screening will be excluded until hormone abnormalities have been corrected.

Where it is running

• Center for Neurolgoical Studies (CNS) — Dearborn, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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