ALFAOMEGA Master Observational Trial
Recruiting now
Conditions studied: Colorectal Cancer
In brief
AlfaOmega has been designed to streamline the study of the co-evolutionary landscape between tumor and host cells in a cohort of CRC patients, with the aim of understanding how their outcomes can be significantly improved (e.g. reduction of their chance of recurrence and survival improval). This clinical resource for integrative clinical data and sample collection will allow the molecular story-telling of CRC metastatic spread along time and space and the selection of appropriate patients for experimentally-driven trials.
Key facts
- Study ID
- NCT04120935
- Run by
- IFOM ETS - The AIRC Institute of Molecular Oncology
- People needed
- 3000
- Starts
- 2019-10-15
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-08-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- TIER1 written Informed consent.
- Patients ≥18 years of age.
- Previous diagnosis of colorectal cancer, or a strong suspicion of CRC based on clinical and radiological findings.
- In patients with previous diagnosis of CRC availability of diagnostic Formalin-Fixed, Paraffin Embedded (FFPE) blocks (surgical resection and/or tumor biopsies), or at least 10 slides (preferably 20). FFPE tissue blocks are always preferred to slides.
- ECOG Performance status < 2.
You may not qualify if…
- Any other current malignancy or malignancy diagnosed or relapsed within the past 5 years (other than non-melanomatous skin cancer, stage 0 melanoma in situ, and in situ cervical cancer)
- Patient unable to comply with the study protocol owing to psychological, social or geographical reasons.
- Known Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or syphilis infection.
Where it is running
- Hospital Moises Broggi — Barcelona, Spain (enrolling)
- IRCCS Istituto Clinico Humanitas — Milan, MI, Italy (enrolling)
- Fondazione IRCCS, Istituto Nazionale dei Tumori — Milan, MI, Italy (enrolling)
- Istituto Europeo di Oncologia (IEO) — Milan, Mi, Italy (enrolling)
- Niguarda Cancer Center - ASST Grande Ospedale Metropolitano Niguarda — Milan, MI, Italy (enrolling)
- Istituto Oncologico Veneto (IOV) — Padova, PD, Italy (enrolling)
- Ospedale Santa Maria della Misericordia — Perugia, Perugia, Italy (enrolling)
- Azienda Ospedaliero Universitaria Pisana — Pisa, Pisa, Italy (enrolling)
- AUSL della Romagna - Ospedale Santa Maria delle Croci — Ravenna, Ravenna, Italy (enrolling)
- Istituto di Candiolo - IRCCS — Candiolo, Torino, Italy (enrolling)
- Azienda Ospedaliero Universitaria San Luigi Gonzaga — Orbassano, Torino, Italy (enrolling)
- Ospedale Policlinico San Martino — Genova, Italy (enrolling)
- Azienda Ospedaliera Universitaria Luigi Vanvitelli — Naples, Italy (enrolling)
- ASL di Biella - Ospedale degli Infermi — Biella, Biella, Italy (enrolling)
- Hospital de Sant Joan Despí Moises Broggi — Barcelona, Barcelona, Spain (enrolling)
- Hospital del Mar - Parc de Salut Mar — Barcelona, Spain, Spain (enrolling)
- Vall d'Hebron Institute of Oncology (VHIO) — Barcelona, Spain, Spain (enrolling)
- INCLIVA - Instituto de Investigatión Sanitaria — Valencia, Spain, Spain (enrolling)
- Azienda Ospedaliera Ordine Mauriziano — Torino, Italy
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.