Progressive Abduction Loading Therapy

Running, not enrolling · Not applicable

Conditions studied: Stroke, Acute

In brief

This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participants with acute/subacute stroke will receive one of two study interventions in addition to prescribed therapies in both inpatient rehabilitation and day-rehab. Participants will be followed for 1 year.

Key facts

Study ID

NCT04118998

Run by

Northwestern University

People needed

86

Starts

2021-08-27

Expected to finish

2027-08-31

Last updated by the study team

2026-08-10

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7)
• Stroke impacting parenchyma of the middle cerebral artery distribution
• Within 90 days post-stroke
• 18 to 85 years old
• No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia)
• No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.)
• Ability to perform a 3-step motor command with the unaffected arm
• Capacity to provide informed consent

You may not qualify if…

• Premorbid and persistent disability or motor impairment of the upper extremities
• Brainstem and/or cerebellar lesion
• Comorbidity medically contraindicating motor assessments
• Any other chronic neurological condition
• Pain or hypersensitivity limiting motor assessments
• Limb edema limiting study motor assessments

Where it is running

• Department of Physical Therapy and Human Movement Sciences — Chicago, Illinois, United States
• Shirley Ryan AbilityLab — Chicago, Illinois, United States
• Northwestern Medicine Marianjoy Rehabilitation Hospital — Wheaton, Illinois, United States

Full record on ClinicalTrials.gov

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