Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder

Completed

Conditions studied: Cannabis Use Disorder

In brief

This research project proposes a novel approach to elucidate the biological adaptations associated with Cannabis Use Disorder and to assess whether such adaptations are predictive of higher drug craving in response to both drug cues and stressors in both the laboratory and real-world, and higher relapse risk and drug use in the real world.

Key facts

Study ID

NCT04116619

Run by

Yale University

People needed

39

Starts

2021-02-01

Expected to finish

2022-02-01

Last updated by the study team

2023-02-21

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cannabis using men and women who:
• 1. Are fluent in English;
• 2. Are using cannabis at levels to match either of the two groups:
• a) Light Users: i. Cannabis using levels of < 1 joint/week ii. Has never met DSM-5 criteria for CUD or other substance use disorders. b) Individuals with Cannabis Use Disorder: i. Meets criteria for CUD based on the SCID (≤ 2 symptoms in past year); ii. Has a past-year cannabis use pattern of ≤3 times per week; iii.Do not meet criteria for any other substance use disorders other than mild Alcohol Use Disorder.
• 3. Provide a negative breathalyzer for alcohol and only positive for cannabis use at all appointments;
• 4. Can provide written informed consent.

You may not qualify if…

• 1. Meets current or past DSM-5 criteria for Axis I for major psychiatric disorders, other than depression or anxiety disorder;
• 2. Meets criteria for a current Substance Use Disorder other than Cannabis or mild Alcohol Use Disorder;
• 3. Has any significant current medical conditions requiring medication, including neurological, renal, thyroid, cardiovascular, liver, endocrine, or immune conditions;
• 4. Reports current use of medications/drugs that interfere with HPA axis response,
• 5. Are women who are pregnant or lactating, are peri-/post-menopausal, or those with hysterectomies;
• 6. Report current use of psychotropic drugs other than antidepressants.

Where it is running

• Yale Stress Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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