Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia

Recruiting now

Conditions studied: Congenital Diaphragmatic Hernia

In brief

CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia. Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining the non-response to iNO, and that these cardiac findings were associated with poor outcomes. Our hypothesis: CDH newborns persist to have some degree of LV hypoplasia in the pediatric and adolescent life and pulmonary pressures remain increased during growth. Patients with decreased cardiac performance by STE and/or with PH have higher concomitant neonatal or pediatric morbidities and altered neurodevelopmental profile

Key facts

Study ID
NCT04114578
Run by
McGill University Health Centre/Research Institute of the McGill University Health Centre
People needed
80
Starts
2019-10-01
Expected to finish
2025-06-30
Last updated by the study team
2024-11-22

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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