Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction
Completed · Not applicable
Conditions studied: Opiate Use Disorder
In brief
In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addiction; clinical outcomes will be assessed before, immediately and three months after treatment. Results could point to factors that track and predict recovery with treatment, offering clinicians markers that can be used for enhancing precision medicine with the goal of reducing morbidity and mortality associated with opiate addiction.
Key facts
- Study ID
- NCT04112186
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 157
- Starts
- 2020-06-21
- Expected to finish
- 2024-09-11
- Last updated by the study team
- 2026-07-24
Who can join
Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ability to understand and give informed consent
- Males and Females 18-64 years of age
- DSM-5 diagnosis of OUD with heroin as the primary drug of choice
- Stabilized on methadone or other form of MAT.
- Inclusion criteria for healthy controls:
- The same as inclusion criteria 1-2 above; dependence on nicotine or caffeine is non-exclusionary.
You may not qualify if…
- DSM-5 diagnosis for schizophrenia or developmental disorder (e.g., autism)
- Head trauma with loss of consciousness
- History of neurological disease of central origin including seizures
- Cardiovascular disease including high blood pressure and/or other medical conditions, including metabolic, endocrinological,oncological or autoimmune diseases, and infectious diseases common in iOUD including Hepatitis B and C or HIV/AIDS
- Metal implants or other MR contraindications
- Exclusion criteria for healthy control subjects:
- The same, except history of any drug use disorder is prohibitive.
Where it is running
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
Full record on ClinicalTrials.gov
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