NIRS in Congenital Heart Defects - Correlation With Echocardiography
Recruiting now
Conditions studied: Congenital Heart Defect, Single-ventricle, Coarctation of Aorta, Atrioventricular Canal, Hypoplastic Left Heart, Transposition of Great Vessels, Interrupted Aortic Arch, Tricuspid Atresia, Pulmonary Atresia, Aortic Atresia, Tetralogy of Fallot
In brief
Neonatal patients with congenital heart defects (CHD) have changing physiology in the context of transitional period. Patients with CHD are at risk of low perfusion status or abnormal pulmonary blood flow. Near infrared spectroscopy has been used in neonatal intensive care units (NICU) to measure end-organ perfusion. The investigator plan on monitoring newborns with CHD admitted to the NICU with NIRS and echocardiography during the first week of life and correlate measures of perfusion from Dopplers to cerebral and renal NIRS.
Key facts
- Study ID
- NCT04106479
- Run by
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- People needed
- 100
- Starts
- 2019-10-11
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-06-17
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A prospective study will be conducted of all newborns with tetralogy of fallot, trucus arteriosus, D-transposition of great arteries, PS, AS, coarctation of the aorta, DILV, AVC, DORV, HLHS, TA and PAIVS consecutively admitted at our institution (Montreal Children's Hospital) neonatal intensive care unit (NICU) from January 2018 to January 2020. Patients with CHD will be compared to a control population of term infants admitted and monitored in the NICU with antenatal suspicion of coarctation, ruled-out postnatally.
You may not qualify if…
- Patients will be excluded if premature less than 34 weeks of estimated gestational age (GA) at birth or if parents do not consent. Parental consent can be withdrawn at any time during the study.
Where it is running
- Mcgill University Health Centre — Montreal, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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