Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome
Stopped early · Not applicable
Conditions studied: Metabolic Syndrome, PreDiabetes, Hypertension, Obesity, Hyperlipidemias
In brief
The purpose of the Exerci-Zzz Study is to learn more about how the time of day that exercise is performed influences sleep quality and fat metabolism overnight in adults with metabolic syndrome. In this study, exercise will be performed in the early evening and the investigators will measure participants' sleep quality and fat metabolism overnight in a metabolic room. The total study will take approximately 2-3 months to complete. Enrolled participants will complete 2 study conditions (evening exercise and control) in a metabolic room. Each of these visits will last 30 hours and require that the participant stay in the metabolic room. During the evening exercise participants will be asked to perform exercise in the early evening. Finally, during the control condition participants will be asked spend the day in the metabolic room (no exercise performed during this condition). During each of these conditions, the investigators will measure participant sleep quality and fat metabolism overnight. In the morning, the investigators will perform a metabolic test to assess the responses of certain hormones. Findings from this study will identify how exercise influences novel contributors to metabolic syndrome (sleep quality and nocturnal metabolism) and shed light on some potential mechanisms to explain the variability in exercise responses.
Key facts
- Study ID
- NCT04105218
- Run by
- University of Colorado, Denver
- People needed
- 12
- Starts
- 2019-08-15
- Expected to finish
- 2021-03-02
- Last updated by the study team
- 2021-08-06
Who can join
Age: 19 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- not currently meeting physical activity guidelines (<150 minutes moderate to vigorous physical activity per week);
- weight stable (<5% change in weight over the last 6 months);
- habitual sleep duration of 7-8 hours and consistent sleep/wake schedule (<1 hour variation night-to-night).
You may not qualify if…
- body mass index >35.0 kg/m2; pregnancy;
- post-menopausal status in women, confirmed by absences of menses for >1 year and elevated follicular stimulating hormone concentrations (>50 mIU/mL); women on oral contraceptives;
- self-reported diabetes, cardiovascular disease, or sleep disorder;
- untreated hyper/hypothyroidism, cancer;
- inability to perform moderate to vigorous treadmill exercise;
- shiftwork
Where it is running
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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