Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

Recruiting now

Conditions studied: Giant Cell Arteritis, Polymyalgia Rheumatica

In brief

A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.

Key facts

Study ID

NCT04102930

Run by

University of Leeds

People needed

4500

Starts

2005-06-10

Expected to finish

2028-03-31

Last updated by the study team

2025-03-30

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean.
• Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms.
• Able and willing to give informed consent. Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA.

You may not qualify if…

• Patient unwilling or unable to give fully informed consent.

Where it is running

• Whiston Hospital — Prescot, Merseyside, United Kingdom (enrolling)
• Royal Devon and Exeter Hospital, Royal Devon and Exeter NHS Foundation Trust — Exeter, United Kingdom (enrolling)
• Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust — Aylesbury, United Kingdom (enrolling)
• Betsi Cadwaladr University Health Board — Bangor, United Kingdom (enrolling)
• Queen Elizabeth The Queen Mother Hospital — Canterbury, Kent, United Kingdom (enrolling)
• Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust — Basildon, United Kingdom (enrolling)
• Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust — Basingstoke, United Kingdom (enrolling)
• Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust — Bath, United Kingdom (enrolling)
• Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
• Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
• Nevill Hall Hospital, Aneurin Bevan University Health Board — Abergavenny, United Kingdom (enrolling)
• Queen's Hospital, University Hospitals of Derby and Burton NHS Foundation Trust — Burton-on-Trent, United Kingdom (enrolling)
• West Suffolk Hospital, West Suffolk NHS Foundation Trust — Bury St Edmunds, United Kingdom (enrolling)
• Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust — Cambridge, United Kingdom (enrolling)
• Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust — Chelsea, United Kingdom (enrolling)
• West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust — Chelsea, United Kingdom (enrolling)
• Ashford and St Peter's Hospitals, Ashford & St Peter's Hospitals NHS Foundation Trust — Chertsey, United Kingdom (enrolling)
• Countess of Chester Hospital, Countess of Chester NHS Foundation Trust — Chester, United Kingdom (enrolling)
• Christchurch Hospital, University Hospitals Dorset NHS Foundation Trust — Christchurch, United Kingdom (enrolling)
• Croydon University Hospital, Croydon Health Service NHS Trust — Croydon, United Kingdom (enrolling)
• Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust — Darlington, United Kingdom (enrolling)
• Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust — Derby, United Kingdom (enrolling)
• Doncaster Royal Infirmary, Doncaster and Bassetlaw Hospitals NHS Foundation Trust — Doncaster, United Kingdom (enrolling)
• Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust — Bristol, United Kingdom (enrolling)
• Gateshead Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust — Gateshead, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.