Mindfulness in Chronic Kidney Disease
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Chronic Kidney Diseases
In brief
This study will test whether mindfulness meditation (MM) improves sympathetic function in chronic kidney disease (CKD) and whether transcutaneous vagus nerve stimulation (tVNS) optimizes the sympatho-inhibitory effects of mindfulness meditation (MM) and restores autonomic balance in CKD patients.
Key facts
- Study ID
- NCT04099992
- Run by
- Emory University
- People needed
- 150
- Starts
- 2019-09-20
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2025-10-21
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- stages III and IV CKD as defined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation
- stable renal function (no greater than a decline of eGFR of 1 cc/min/1.73 m2 per month over the prior 3 months)
You may not qualify if…
- severe CKD (eGFR<15 cc/min)
- diabetic neuropathy
- autonomic dysfunction
- any serious disease that might influence survival
- anemia with hemoglobin <10 g/dL
- treatment with central α-agonists or monoamine oxidase (MAO) inhibitors
- myocardial infarction or cerebrovascular accident within the past 6 months
- uncontrolled hypertension (BP≥170/100 mm Hg)
- low BP (BP<100/50 mm Hg)
- bradycardia (HR<55 beats/min)
- ongoing drug or alcohol abuse (defined as >2 drinks/day in men, and >1 drink/day in women)
- surgery within the past 3 months
- adjustment of antihypertensive medications within the past month
- pregnancy or plans to become pregnant
- psychosis
- suicidal ideation
- implanted electronic or metallic device such as a pacemaker
- implanted hearing aid, bone plate, carotid stent, bone screw at or near the neck
- carotid atherosclerosis
- concurrent use of another stimulating device such as a transcutaneous electrical nerve stimulation (TENS) unit
Where it is running
- Atlanta VA Medical Center — Atlanta, Georgia, United States (enrolling)
Full record on ClinicalTrials.gov
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