An Open Label Study of Bavituximab and Pembrolizumab in Advanced Gastric and GEJ Cancer Patients

Completed · Phase 2

Conditions studied: Gastric Cancer, GastroEsophageal Cancer

In brief

This study evaluates the combination of bavituximab and pembrolizumab in the treatment of gastric and gastroesphogeal cancer. All patients will receive both bavituximab, a drug that is not yet approved by the FDA, and pembrolizumab known as Keytruda. There is no expanded access program available for the investigational agents per this protocol.

Key facts

Study ID

NCT04099641

Run by

OncXerna Theraputics, Inc.

People needed

80

Starts

2019-09-11

Expected to finish

2022-10-26

Last updated by the study team

2023-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed written informed consent
• Men and women ≥ 18 years old; ≥ 20 years old in South Korea and Taiwan
• Unresectable metastatic or locally advanced gastric or GEJ adenocarcinoma
• Progressed on and/or after at least 1 prior regimen for metastatic disease or achieved stable disease or better in two consecutive scans to PD-1/PD-L1 inhibition alone or in combination with chemotherapy and relapsed
• Willing and able to provide fresh formalin-fixed paraffin-embedded tissue tumor sample
• Presence of at least one measurable lesion
• ECOG of 0 or 1
• Has adequate organ functions
• Women of childbearing potential must have a negative serum or urine pregnancy test within 72 hours prior to start of study treatment.
• Women must not be breastfeeding.
• Women of childbearing potential , must agree to follow instructions for highly effective method(s) of contraception
• Males who are sexually active with women of childbearing potential must agree to follow instructions for highly effective method(s) of contraception
• Has adequate treatment washout period before start of study treatment

You may not qualify if…

• Received any form of anti-phosphatidylserine therapies
• Prior treatment with any checkpoint inhibitor or other therapies targeting T-cell control
• Known microsatellite instability-high (MSI-H) gastric or GEJ adenocarcinoma
• Medical history of myocardial infarction within 6 months before registration, symptomatic congestive heart failure (CHF) , troponin levels consistent with myocardial infarction, unstable angina, or serious cardiac arrhythmia
• Weight loss >10% over 2 months prior to first dose of study treatment
• History of pneumonitis that required steroids or has current pneumonitis
• Has known active CNS metastases/and or carcinomatous meningitis
• Known additional malignancy that is progressing or has required active treatment in within the past 3 years
• An active infection requiring systemic therapy
• Known human immunodeficiency virus (HIV) infection or known acute hepatitis B or C infection
• Unresolved toxicities from previous cancer treatments
• History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the treating investigator
• Active autoimmune disease or history of chronic recurrent autoimmune disease
• Severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients.
• History of infusion reactions to any component/excipient of bavituximab
• History of severe hypersensitivity reactions to mAbs.
• Systemic steroid therapy within 7 days prior to the first dose of study treatment
• Has received a live vaccine within 30 days prior to first dose of study drug.
• Prior organ transplantation including allogeneic or autologous stem-cell transplantation
• Currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment
• Receipt of treatment with immunotherapy, biological therapies, or therapeutic doses of hormonal therapies within 3 weeks of scheduled C1D1 dosing
• Known psychiatric, substance abuse disorder, or geographical travel limitations that would interfere with participant's ability to cooperate with the requirements of the study
• Pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study

Where it is running

• Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut, United States
• Cleveland Clinic Florida - Weston — Weston, Florida, United States
• Columbus Regional Research Institute — Columbus, Georgia, United States
• The University of Chicago Medical Center — Chicago, Illinois, United States
• Siteman Cancer Center - Washington University Medical Campus — St Louis, Missouri, United States
• White Plains Hospital - Center for Cancer Care — White Plains, New York, United States
• UC Health Office of Clinical Research — Cincinnati, Ohio, United States
• Cancer Treatment Centers of America at Eastern Regional Medical Center — Philadelphia, Pennsylvania, United States
• Sara Cannon Research Institute — Nashville, Tennessee, United States
• Dong-A University Hospital — Busan, South Korea
• Kyungpook National University Chilgok Hospital — Daegu, South Korea
• Seoul National University Bundang Hospital — Seongnam-si, South Korea
• Asan Medical Center — Seoul, South Korea
• Samsung Medical Center — Seoul, South Korea
• Seoul National University Hospital — Seoul, South Korea
• China Medical University Hospital — Taichung, Taiwan
• National Cheng Kung University Hospital — Tainan, Taiwan
• Taipei Veterans General Hospital — Taipei, Taiwan
• Chang Gung Medical Foundation - Linkou Branch — Taoyuan, Taiwan
• The Royal Marsden — London, United Kingdom
• Sarah Cannon Research Institute — London, United Kingdom

Full record on ClinicalTrials.gov

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