Investigating the Effect of Dronabinol on Post-surgical Pain

Withdrawn before enrolling · Early Phase 1

Conditions studied: Knee Replacement, Arthropathy of Knee

In brief

This study is designed to investigate the effect of dronabinol on post operative pain in patients undergoing total knee replacement (for their own clinical care).

Key facts

Study ID

NCT04099355

Run by

New York State Psychiatric Institute

People needed

0

Starts

2025-09-01

Expected to finish

2027-08-30

Last updated by the study team

2023-11-13

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants undergoing total knee arthroplasty (TKA) at the CUIMC department of orthopedic surgery as part of their clinical care.
• Able to give informed consent and comply with study procedures in English

You may not qualify if…

• Meet DSM-V criteria for current major psychiatric illness, such as bipolar disorder, major depression, or psychosis. Subjects with a current substance use disorder will be excluded. Subjects with a past cannabis use disorder are excluded.
• Diagnosis of a major medical or neurological disorder, including orthostatic hypertension, cardiovascular disease (congestive heart failure, unstable angina, or a history of cardiac infarction), hypotension, or neurodegenerative disorders.
• Subjects taking medications that can lead to a drug interaction.

Where it is running

• 1051 Riverside Drive — New York, New York, United States

Full record on ClinicalTrials.gov

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