Improving White Matter Integrity With Thyroid Hormone

Completed

Conditions studied: Hypothyroidism

In brief

Animal studies have shown that thyroid hormone can improve white matter integrity after damage to myelin, which insulates and protects nerves. It is currently unknown whether this type of repair can occur in humans. The purpose of the proposed study is to examine the impact of thyroid hormone on white matter integrity in humans using two complementary, state-of-the-art neuroimaging techniques: high angular diffusion imaging and multicomponent relaxometry.

Key facts

Study ID

NCT04098991

Run by

University of Illinois at Chicago

People needed

5

Starts

2017-11-08

Expected to finish

2019-11-08

Last updated by the study team

2020-04-10

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 21-60 years of age
• A diagnosis of primary hypothyroidism from autoimmune thyroiditis (Hashimoto)
• Able to give informed consent.

You may not qualify if…

• Major depressive disorder with or without active suicidal ideation
• Mild or major neurocognitive disorder;
• Presence of contraindications to magnetic resonance imaging (presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)
• Inability to tolerate small, enclosed spaces without anxiety (e.g., claustrophobia)
• Unwilling/unable to sign informed consent document
• Positive urine drug screen results;
• Pregnancy (positive pregnancy test), trying to become pregnant, or lactation

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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