Pain Catastrophizing and Prescription Opioid Craving

Stopped early · Not applicable

Conditions studied: Chronic Pain

In brief

Adherence to prescription opioid and opioid tapering as indicated are critical for safe chronic opioid therapy for chronic pain, but this can be difficult for patients experiencing prescription opioid craving. Because pain catastrophizing is proposed as a possible treatment target by our and others' preliminary results, the proposed study aims to determine whether pain catastrophizing is a treatment target to reduce prescription opioid craving and to investigate whether negative affect and stress hormones are potential mediators. The findings from the current study will inform whether a psychology intervention to lower pain catastrophizing will reduce opioid craving, and whether psychological and physical distress as well as cognitive function will be potential mediators of the treatment effect.

Key facts

Study ID

NCT04097743

Run by

Stanford University

People needed

93

Starts

2021-06-29

Expected to finish

2024-12-10

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years
• Chronic pain ( > 3months)
• Prescription opioid use (>3 months)

You may not qualify if…

• Current diagnosis of cancer
• Concurrent psychological therapy
• Other severe psychiatric conditions (schizophrenia, delusional disorder, psychotic disorder, dissociative disorder, and active suicidality)
• Any skin conditions on the hand (pain testing site)
• Non-English speaker
• No access to email or smart phone

Where it is running

• Stanford Pain Relief Innovations Lab — Palo Alto, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.