Comparison of Sugammadex and Neostigmine During PACU Stay

Starting soon · Phase 3

Conditions studied: Neuromuscular Blockade

In brief

Sugammadex was approved for post-operative use in the operating room (OR) and post-anesthesia recovery unit (PACU) of our quaternary facility, Tampa General Hospital. The approval came with administrative limitations: 2mg/kg dose only and for the first year its utilization was limited as replacement for up to half of Neostigmine/Glycopyrrolate use. An MUE evaluation was completed for a retrospective chart review from March 2017 to December 2017 (10 months) to assess all cases in which patients received Sugammadex or Neostigmine. During the year of data collection, we also noted a widespread tendency to reduce the usage of narcotics. A t-test comparison of the length of stay (LOS) in the PACU revealed a highly significant difference between the LOS in PACU for both drugs. On average, patients receiving Sugammadex were discharged from the PACU 43 minutes earlier than patients who received Neostigmine/Glycopyrrolate. The patient mix in both groups was similar, but these data were obtained retrospectively by a pharmacy chart review.

Key facts

Study ID

NCT04096144

Run by

University of South Florida

People needed

50

Starts

2019-10-15

Expected to finish

2020-06-15

Last updated by the study team

2019-09-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-75 years of age
• Patients with surgeries with duration of 90-120 minutes
• ASA Patients I-III (Appendix A)
• Patients admitted to TGH for abdominal hernia repair, cholecystectomy and/or abdominal surgery as performed by Dr. Albrink
• BMI > 30

You may not qualify if…

• <18 years of age
• ASA Patients IV and above (Appendix A)
• Patients with allergic reactions to Neostigmine+Glycopyrrolate and/or Sugammadex

Where it is running

• Tampa General Hospital — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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