Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury

Completed

Conditions studied: Acute Kidney Injury, Fluid Overload, Ultrasonography

In brief

Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congestion and its clinical implications. The objective of this study is to determine whether ultrasound markers of organ congestion are associated with major adverse kidney events in critically ill patients with severe acute kidney injury.

Key facts

Study ID

NCT04095143

Run by

Centre hospitalier de l'Université de Montréal (CHUM)

People needed

125

Starts

2018-09-04

Expected to finish

2022-09-01

Last updated by the study team

2022-11-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Admitted to the ICU
• Women with serum creatinine ≥ 100 µmol/L and men with serum creatinine ≥ 130 µmol/L
• Severe acute kidney injury (AKI) defined either: A ≥ 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization OR achievement of a serum creatinine ≥ 354 µmol/L with evidence of a minimum increase of 27 µmol/L from pre-morbid baseline or during the current hospitalization OR Urine output < 6.0 mL/kg over the preceding 12 hours OR initiation of renal replacement therapy (RRT) for severe AKI initiated less than 72 hours before recruitment.

You may not qualify if…

• Lack of commitment to provide RRT as part of limitation of ongoing life support. (Operational definition: Critical care team has deemed the patient not to be eligible for escalation of life support, including the initiation of RRT, or substitute decision makers have declined offer of same.)
• Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate < 20 mL/min/1.73 m2 in a patient who is not on chronic RRT. (Operational definition: The coordinator will review all documented serum creatinine values within 365 days prior to the date of admission for the current hospitalization. The value closest to the admission date will be considered as the "baseline" and will be used to calculate the corresponding estimated glomerular filtration rate using an online calculator. A value of < 20 mL/min/1.73 m2 derived from the CKD-EPI equation will be grounds for exclusion.

Where it is running

• University of Kentucky — Lexington, Kentucky, United States
• University of Alberta — Edmonton, Alberta, Canada
• Sunnybrook Health Science Centre — Toronto, Ontario, Canada
• St. Michael's hospital — Toronto, Ontario, Canada
• Centre Hospitalier de l'Université de Montréal — Montreal, Quebec, Canada
• Montreal Heart Institute — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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