Ashwagandha for Cognitive Dysfunction

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Chemo Fog

In brief

This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.

Key facts

Study ID

NCT04092647

Run by

Sutter Health

People needed

80

Starts

2023-01-01

Expected to finish

2025-07-01

Last updated by the study team

2023-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years and older
• English speaking
• Currently undergoing chemotherapy or treatment with chemotherapy in the past year
• Self-reported memory loss, attention, visual-spatial functioning, reasoning, or information processing or cognitive changes in the first 2 cycles of chemotherapy and score < 63 on the FACT-Cog PCI
• Able to follow instructions for testing and comply with testing
• Able to swallow pills

You may not qualify if…

• Undergoing treatment for any hormone dependent cancer
• Planned surgical treatment
• History of pre-existing dementia, untreated depression, psychiatric disorder, prior brain radiation or brain injury
• History of hypotension
• Active autoimmune disease
• Brain metastasis
• Taking any drugs daily that would alter cognition
• Concurrent use of benzodiazepenes or other sedatives
• Concurrent use of supplements that can cause sedation such as 5-HTP, calamus, California poppy, hops, Jamaican dogwood, kava, St.John's Wort, skullcap, valerian, yerba mansa
• Currently taking hypoglycemic medications
• History of substance abuse
• Current or recent diagnosis of stomach ulcer or gastritis

Where it is running

• Sutter Cancer Center — Sacramento, California, United States (enrolling)

Full record on ClinicalTrials.gov

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