TRAIN-BW: Backward Walking Training in Multiple Sclerosis

Running, not enrolling · Not applicable

Conditions studied: Multiple Sclerosis, Gait Disorders, Neurologic, Accidental Fall

In brief

Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pronounced in backward walking (BW), yet no studies have investigated BW training as an intervention to reduce fall risk in persons with MS. This study will investigate the feasibility, acceptability and impact of BW training compared to forward walking training on motor function and fall risk in persons with MS.

Key facts

Study ID

NCT04091464

Run by

Wayne State University

People needed

90

Starts

2020-01-01

Expected to finish

2026-02-28

Last updated by the study team

2025-12-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of MS
• PDDS <6, indicating ability to ambulate with or without an assistive device >/= 50% of the time
• Self-reported walking dysfunction as evidenced by a score of >/= 30 on MSWS-12 OR reports of 2 or more falls in the prior 6 months, indicating a frequent faller.

You may not qualify if…

• MS relapse within the past 30 days
• comorbid neurological disorder
• acute orthopedic disorder/injury
• unable to follow study-related commands

Where it is running

• Wayne State University — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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