The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
Completed · Not applicable
Conditions studied: Peripheral Arterial Disease, Vascular Diseases, Peripheral, Arterial Occlusive Diseases, Atherosclerosis
In brief
MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.
Key facts
- Study ID
- NCT04089943
- Run by
- University of West Florida
- People needed
- 230
- Starts
- 2019-09-15
- Expected to finish
- 2025-08-25
- Last updated by the study team
- 2026-02-23
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- male or female 30 years or older,
- Infrainguinal PAD,
- critical limb ischemia, defined as arterial insufficiency with gangrene, nonhealing ischemic ulcer, or rest pain consistent,
- candidate for both endovascular and open infra-inguinal revascularization as judged by the vascular surgeons,
- absence of musculoskeletal (most commonly arthritis related) or neurologic (most commonly back pain and sciatica related) symptoms,
- willingness to comply with protocol, attend follow-up appointments, complete all study assessments, and provide written informed consent.
You may not qualify if…
- life expectancy of less than 2 years due to reasons other than PAD,
- acute lower extremity ischemic event secondary to thromboembolic disease or acute trauma,
- current chemotherapy or radiation therapy
Where it is running
- UT Austing Dell Medical School — Austin, Texas, United States
- Baylor Scott and White — Temple, Texas, United States
Full record on ClinicalTrials.gov
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